Gustaitis is in red-hot form after helping the USA finish fourth at the World Cup Sevens last month.
Ash Kara captained UC in the inaugural series last year and will lead a young squad full of exciting talent and proven stars.
“We’ve selected a squad that will challenge for honours,” Grimmond said.
“Almost half the girls who played last year are back again and they’re stronger with that experience under their belts.
“There’s a lot of new talent in the mix, too, which has made us stronger and more versatile. We’ve gained players from a variety of other sports who have made the transition to sevens very smoothly.
“We had a lot of women interested in playing this year which shows how popular this form of the game is. It’s a great sign for rugby, but it did give us a few selection headaches.”
UC will host the second round of the series September 8-9.
University of Canberra squad: Tania Afamasaga, Shelley Bradshaw, Kirra Burke, Louise Burrows, Bridgette Cunningham, Biola Dawa, Kasey Dragisic, Ngawai Eyles, Courtney Frankl, Jane Garraway, Abby Gustaitis, Regan Hart, Ash Kara, Michaela Leonard, Paremo March, Ema Masi, Yasmin Meakes, Kiara Meredith-Brown, Claudia Obst, Georgia O’Niell, Steph Pollard, Darcy Read, Tayla Stanford, Bree Toze, Sammie Wood